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Welcome to the home page of the Biological Crystallography Facility at the NSRRC (BioNSRRC). Biological Crystallography is a technique that can determinate the 3-D molecular structures of biological macromolecules from their single crystals. The goal of BioNSRRC is to provide users with a sophisticated research facility, including a full complement of instrumentation, software, and support for high-throughput data collection and processing. We also provide professional discussions and substantial user support; therefore both experienced and non-experienced users are all welcome to use this facility. Worldwide researchers can access to this facility through the NSRRC proposal submitting procedure.

BioNSRRC Beamline
  Location
SPring-8, Japan
NSRRC, Taiwan
NSRRC, Taiwan
NSRRC, Taiwan
NSRRC, Taiwan
  X-ray Source
BM on 8
GeV SPring8
Wiggler on
1.5GeV TLS
Wiggler on
1.5GeV TLS
Wiggler on
1.5GeV TLS
Undulator on
3GeV TPS
  General User Time
50%
75%
75%
75%
75%
  Status
Operational
Operational
Operational
Operational
Constructing
  Experiment
MAD
MAD
Mono/SAD
MAD
Minibeam/MAD
  Wavelength (Å)
1.77-0.54
1.77-0.69
0.975
2.21-0.8
2.26-0.62
  Energy Range (keV)
7-23.0
7-18
12.7
5.6-15.5
5.7-20.0
  Defined Beam Size (μmΦ)
200
200x140
150x100
200/150/100/75/50
50/30/20/10/5
  Flux After Def. Beam (p/s)
1.5x1011
4x1011
6.7x1010
20/8/5/2/1.3x1010
440/250/130/35/8.5x1010
  Detector 
MX225HE
Q315r
Q315r
MX300HE
MX300HS
  Detector Size (mm2)
225x225
315x315
315x315
300x300
300x300
  Xtal-Detector (mm)
120-800
130-800
110-900
100-850
-
  Throughput (images/min)
20
20
20
20
-
SPACE
SAM
SAM
SAM
SAM
No
Yes
Yes
Yes
Yes
No
Yes
Yes
Yes
Yes

 Historical Events

   The first de-novo structure solved at BioNSRRC on 2001

   The first protein structure selected as the Research Highlights of 2008 by NIH, USA

   The first membrane protein structure solved at BioNSRRC on 2009

   Human topoisomerase IIbeta in complex with DNA and etoposide solved at BioNSRRC on 2011

   Membrane embedded H1-translocating pyrophosphatase solved at BioNSRRC on 2012

 Funding Agencies

   Ministry of Science and Technology, Taiwan, ROC

   National Research Program for Genomic Medicine

   National Core Facility Program for Biotechnology

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