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Welcome to the home page of the Biological Crystallography Facility at the NSRRC (BioNSRRC). Biological Crystallography is a technique that can determinate the 3-D molecular structures of biological macromolecules from their single crystals. The goal of BioNSRRC is to provide users with a sophisticated research facility, including a full complement of instrumentation, software, and support for high-throughput data collection and processing. We also provide professional discussions and substantial user support; therefore both experienced and non-experienced users are all welcome to use this facility. Worldwide researchers can access to this facility through the NSRRC proposal submitting procedure.

BioNSRRC Beamline	SP12B2	BL13B1	BL13C1	BL15A1	TPS-05A1
Location	SPring-8, Japan	NSRRC, Taiwan	NSRRC, Taiwan	NSRRC, Taiwan	NSRRC, Taiwan
X-ray Source	BM on 8 GeV SPring8	Wiggler on 1.5GeV TLS	Wiggler on 1.5GeV TLS	Wiggler on 1.5GeV TLS	Undulator on 3GeV TPS
General User Time	50%	75%	75%	75%	75%
Status	Operational	Operational	Operational	Operational	Constructing
Experiment	MAD	MAD	Mono/SAD	MAD	Minibeam/MAD
Wavelength (Å)	1.77-0.54	1.77-0.69	0.975	2.21-0.8	2.26-0.62
Energy Range (keV)	7-23.0	7-18	12.7	5.6-15.5	5.7-20.0
Defined Beam Size (μmΦ)	200	200x140	150x100	200/150/100/75/50	50/30/20/10/5
Flux After Def. Beam (p/s)	1.5x10¹¹	4x10¹¹	6.7x10¹⁰	20/8/5/2/1.3x10¹⁰	440/250/130/35/8.5x10¹⁰
Detector	MX225HE	Q315r	Q315r	MX300HE	MX300HS
Detector Size (mm²)	225x225	315x315	315x315	300x300	300x300
Xtal-Detector (mm)	120-800	130-800	110-900	100-850	-
Throughput (images/min)	20	20	20	20	-
Sample Changer	SPACE	SAM	SAM	SAM	SAM
Remote Access	No	Yes	Yes	Yes	Yes
Mail-In Service	No	Yes	Yes	Yes	Yes

Historical Events

The first de-novo structure solved at BioNSRRC on 2001

The first protein structure selected as the Research Highlights of 2008 by NIH, USA

The first membrane protein structure solved at BioNSRRC on 2009

Human topoisomerase IIbeta in complex with DNA and etoposide solved at BioNSRRC on 2011

Membrane embedded H1-translocating pyrophosphatase solved at BioNSRRC on 2012

Funding Agencies

Ministry of Science and Technology, Taiwan, ROC

National Research Program for Genomic Medicine

National Core Facility Program for Biotechnology